DNA ligase is an enzyme that plays a crucial role in the process of DNA replication and repair. Its main function is to join together the DNA fragments that are created during the process of DNA replication or due to damage to the DNA molecule. DNA ligase works by creating phosphodiester bonds between the sugar-phosphate backbones of adjacent DNA fragments, sealing the breaks in the DNA strand.
During DNA replication, DNA ligase is responsible for joining the Okazaki fragments on the lagging strand of the DNA molecule, creating a continuous and intact DNA strand. In cases of DNA damage, such as breaks or gaps in the DNA molecule, DNA ligase helps to repair the damage by joining the broken ends of the DNA strand.
Overall, DNA ligase is essential for maintaining the integrity of the DNA molecule and ensuring that the genetic information is accurately replicated and preserved. It plays a key role in various cellular processes, including DNA replication, DNA repair, and genetic recombination.
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